MilliporeSigma™ Mouse anti-ACD, Clone: 1G10.3,

Catalog No.	Quantity
MABE903MI	100 μg

Catalog No. MABE903MI Supplier MilliporeSigma™ Supplier No. MABE903

Description

Mouse Monoclonal Antibody

Specifically detects ACD clone: 1G10.3 in Human samples, and it is validated for Immunocytochemistry, Western Blotting

Adrenocortical dysplasia protein homolog (also known as POT1 and TIN2 organizing protein or TIN2-interacting protein) is a nuclear protein encoded by the ACD gene in human (also known as PIP1, PTOP, TINT1, TPP1). It a component of the shelterin complex (telosome) and is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance, and chromosome ends are inappropriately processed by DNA repair pathways. The ACD-POT1 heterodimer is reported to enhance telomere elongation by increasing telomerase processivity (PMID 17237768).

Specifications

• Antigen: ACD
• Applications: Immunocytochemistry, Western Blot
• Classification: Monoclonal
• Clone: 1G10.3
• Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q96AP0
• Gene Symbols: ACD; PIP1; PTOP; TINT1; TPP1
• Host Species: Mouse
• Immunogen: GST-tagged recombinant protein corresponding to human ACD.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Epigenetics and Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001075955
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG2a κ

For Research Use Only