MilliporeSigma™ Mouse anti-ACD, Clone: 1G10.3,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABE903

Catalog No. MABE903MI

Description

Specifically detects ACD clone: 1G10.3 in Human samples, and it is validated for Immunocytochemistry, Western Blotting

Adrenocortical dysplasia protein homolog (also known as POT1 and TIN2 organizing protein or TIN2-interacting protein) is a nuclear protein encoded by the ACD gene in human (also known as PIP1, PTOP, TINT1, TPP1). It a component of the shelterin complex (telosome) and is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance, and chromosome ends are inappropriately processed by DNA repair pathways. The ACD-POT1 heterodimer is reported to enhance telomere elongation by increasing telomerase processivity (PMID 17237768).

Specifications

• Antigen: ACD
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: ACD; PIP1; PTOP; TINT1; TPP1
• Immunogen: GST-tagged recombinant protein corresponding to human ACD.
• Quantity: 100 μg
• Research Discipline: Epigenetics and Nuclear Function
• Gene ID (Entrez): NP_001075955
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG2a κ

• Applications: Immunocytochemistry, Western Blot
• Clone: 1G10.3
• Gene Accession No.: Q96AP0
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only