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CD11c Mouse anti-Human, Unlabeled, Clone: 3.9, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565805

Catalog No. BDB565805


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Description

Description

The 3.9 monoclonal antibody specifically binds to CD11c, which is also known as Integrin alpha X ( α X Integrin/ITGAX), or p150,95 Integrin alpha chain. CD11c is a ~150 kDa type I transmembrane glycoprotein. It is expressed on monocytes, macrophages, granulocytes, NK cells, dendritic cells, and subsets of B and T cells. It associates with CD18 (Integrin beta 2/ β 2 Integrin) to form the CD11c/CD18 complex, which is also known as p150,95 Integrin, or the Type 4 Complement Receptor (CR4). CD11c/CD18 binds fibrinogen and reportedly serves as a receptor for iC3b and ICAM-1/CD54. CD11c/CD18 functions as an adhesion molecule that mediates cellular binding to ligands expressed on stimulated epithelium and endothelium. The 3.9 monoclonal antibody crossreacts with Rhesus macaque leucocytes.

Specifications

Specifications

CD11c
3.9
Unconjugated
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
IgG1, κ
0.1mg
Store undiluted at 4°C
Monoclonal
Flow Cytometry, Immunofluorescence
0.5mg/mL
ITGAX; AlphaX Integrin; Axb2; Integrin alpha-X; CR4; SLEB6; p150,95 alpha
Affinity Purified
Human monocytes and synovial cells
Affinity Chromatography
RUO
Primary
Human, Rhesus
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