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MilliporeSigma™ Mouse anti-alpha-Synuclein (aa 121-125), (Ascites Free), Clone: Syn211,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ 36008C

Catalog No. 36-008-CMI


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Description

Description

Specifically detects alpha-Synuclein (aa 121-125), (Ascites Free) clone: Syn211 in Human samples, and it is validated for Immunohistochemistry, Western Blotting

Alpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human. There are two other known synuclein family members, beta- and gamma-synuclein. Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson's disease (PD). Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388). Clone Syn211, detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

alpha-Synuclein (aa 121-125), (Ascites Free)
Monoclonal
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
SNCA; NACP; PARK1
Conjugated recombinant protein corresponding to human alpha-Synuclein.
100 μg
Neuroscience
NP_000336
Stable for one year at 2°C to 8°C from date of receipt.
IgG1 κ
Immunohistochemistry, Western Blot
Syn211
P37840
Mouse
Protein G Purified
RUO
Primary
Human
Purified
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