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MilliporeSigma™ Mouse anti-alpha-Synuclein (aa 121-125), (Ascites Free), Clone: Syn211,

Catalog No. 36008CMI Shop All MilliporeSigma Products
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36-008-CMI 100 μg
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Catalog No. 36-008-CMI Supplier MilliporeSigma™ Supplier No. 36008C
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Description

Mouse Monoclonal Antibody

Specifically detects alpha-Synuclein (aa 121-125), (Ascites Free) clone: Syn211 in Human samples, and it is validated for Immunohistochemistry, Western Blotting

Alpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human. There are two other known synuclein family members, beta- and gamma-synuclein. Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson's disease (PD). Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388). Clone Syn211, detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).
TRUSTED_SUSTAINABILITY

Specifications

Antigen alpha-Synuclein (aa 121-125), (Ascites Free)
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone Syn211
Formulation Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P37840
Gene Symbols SNCA; NACP; PARK1
Host Species Mouse
Immunogen Conjugated recombinant protein corresponding to human alpha-Synuclein.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_000336
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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