MilliporeSigma™ Mouse anti-alpha-Synuclein (aa 121-125), (Ascites Free), Clone: Syn211,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ 36008C

Catalog No. 36-008-CMI

Description

Specifically detects alpha-Synuclein (aa 121-125), (Ascites Free) clone: Syn211 in Human samples, and it is validated for Immunohistochemistry, Western Blotting

Alpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human. There are two other known synuclein family members, beta- and gamma-synuclein. Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson's disease (PD). Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388). Clone Syn211, detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).

Specifications

• Antigen: alpha-Synuclein (aa 121-125), (Ascites Free)
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: SNCA; NACP; PARK1
• Immunogen: Conjugated recombinant protein corresponding to human alpha-Synuclein.
• Quantity: 100 μg
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_000336
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG1 κ

• Applications: Immunohistochemistry, Western Blot
• Clone: Syn211
• Gene Accession No.: P37840
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only