ANPEP, Mouse, PE, Clone: WM15, Abnova™

Catalog No.	Quantity
89-111-778	100 Reactions

Catalog No. 89-111-778 Supplier Abnova Corporation Supplier No. MAB4356

Description

Mouse monoclonal antibody raised against native ANPEP.

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq

Specifications

• Antigen: ANPEP
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation
• Classification: Monoclonal
• Clone: WM15
• Conjugate: PE
• Description: Mouse monoclonal antibody raised against native ANPEP.
• Dilution: Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 10⁶ cells in a suspension) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.2% BSA, 0.09% sodium azide)
• Gene: ANPEP
• Gene Alias: APN/CD13/LAP1/PEPN/gp150/p150
• Gene Symbols: ANPEP
• Host Species: Mouse
• Immunogen: Native purified ANPEP from human AML cell.
• Quantity: 100 Reactions
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 290
• Test Specificity: This antibody recognizes the human CD13 cell surface glycoprotein, a 150 KDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.
• Target Species: Human, Non-human Primate
• Content And Storage: Store in the dark at 4°C. Do not freeze.
  Avoid prolonged exposure to light.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1