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APAF1, Mouse, Clone: 22D7, Abnova™

Catalog No. 89113231 Shop All Abnova Corporation Products
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Catalog No. Quantity
89-113-231 100 μL
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Catalog No. 89-113-231 Supplier Abnova Corporation Supplier No. MAB7912

Description

Mouse monoclonal antibody raised against recombinant APAF1.

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq

Specifications

Antigen APAF1
Applications ELISA, Western Blot
Classification Monoclonal
Clone 22D7
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against recombinant APAF1.
Dilution Western Blot (1:5000) The optimal working dilution should be determined by the end user.
Formulation In HEPES, 150mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
Gene APAF1
Gene Alias CED4/DKFZp781B1145
Gene Symbols APAF1
Host Species Mouse
Immunogen Recombinant His fusion protein corresponding to human APAF1.
Purification Method Ammonium sulfate precipitation
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 317
Target Species Human
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1
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