APAF1, Mouse, Clone: 2E10, Abnova™

Catalog No.	Quantity
89-111-118	100 μg

Catalog No. 89-111-118 Supplier Abnova Corporation Supplier No. MAB2746

Description

Mouse monoclonal antibody raised against synthetic peptide of APAF1.

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq

Specifications

• Antigen: APAF1
• Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
• Classification: Monoclonal
• Clone: 2E10
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against synthetic peptide of APAF1.
• Dilution: Western Blot (0.25-0.5 mg/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.02% sodium azide)
• Gene: APAF1
• Gene Alias: CED4/DKFZp781B1145
• Gene Symbols: APAF1
• Host Species: Mouse
• Immunogen: A synthetic peptide corresponding to amino acids near C-terminus of human APAF1.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 317
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG