AR, Mouse, Clone: 2F12, Abnova™

Mouse monoclonal antibody raised against recombinant AR.

Supplier:  Abnova Corporation MAB9566

Catalog No. 89-113-690

Description

The androgen receptor gene is more than 90kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq

Specifications

• Antigen: AR
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:25) The optimal working dilution should be determined by the end user.
• Gene: AR
• Gene Symbols: AR
• Immunogen: Recombinant protein corresponding to 321 amino acids near N-terminus of human AR.
• Regulatory Status: RUO
• Gene ID (Entrez): 367
• Content And Storage: Store at 4°C on dry atmosphere. After reconstitution with sterile distilled water store at 4°C for at least two months. For long term storage store at -20°C or below. Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1

• Applications: Immunohistochemistry, Immunohistochemistry (Frozen)
• Clone: 2F12
• Description: Mouse monoclonal antibody raised against recombinant AR.
• Formulation: Lyophilized from tissue culture supernatant (0.09% sodium azide)
• Gene Alias: AIS/DHTR/HUMARA/KD/NR3C4/SBMA/SMAX1/TFM
• Host Species: Mouse
• Quantity: 3 x 1 mL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Lyophilized