ARNT, Mouse, Clone: H1beta234, Abnova™

Catalog No.	Quantity
89-110-967	100 μL

Catalog No. 89-110-967 Supplier Abnova Corporation Supplier No. MAB2370

Description

Mouse monoclonal antibody raised against partial recombinant ARNT.

The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq

Specifications

• Antigen: ARNT
• Applications: Immunohistochemistry, Western Blot
• Classification: Monoclonal
• Clone: H1beta234
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant ARNT.
• Dilution: Western Blot (1:500) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: ARNT
• Gene Alias: HIF-1beta/HIF1B/HIF1BETA/TANGO/bHLHe2
• Gene Symbols: ARNT
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 496-789 of human ARNT.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 405
• Test Specificity: This antibody is specific to HIF-1 beta /ARNT.
• Target Species: Bovine, Ferret, Human, Mouse, Rat, Sheep
• Content And Storage: Store at -20°C or -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1 κ