MilliporeSigma™ Mouse anti-ATRX, Clone: 23C,

Catalog No.	Quantity
MABE897MI	100 μg

Catalog No. MABE897MI Supplier MilliporeSigma™ Supplier No. MABE897

Description

Mouse Monoclonal Antibody

Specifically detects ATRX clone: 23C in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting

Transcriptional regulator ATRX (EC 3.6.4.12; UniProt P46100; also known as Alpha thalassemia/mental retardation syndrome X-linked, ATP-dependent helicase ATRX, DNA dependent ATPase and helicase, Helicase 2 X-linked, X-linked helicase II, X-linked nuclear protein, XNP, Zinc finger helicase, Znf-HX) is encoded by the PRF1 (Also known as ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX) gene in human (Gene ID 546). Rad54 belongs to the SWI/SNF family of chromatin remodeling proteins. Rad54 undergoes cell cycle-dependent phosphorylation, nuclear matrix and chromatin association, and is implicatetd in playing a role in gene regulation during interphase and mitosis. ATRX mutations are associated with an X-linked mental retardation (XLMR) syndrome. most often accompanied by alpha-thalassemia syndrome, as a result of diverse changes in DNA methylation.

Specifications

• Antigen: ATRX
• Applications: Immunocytochemistry, Western Blot
• Classification: Monoclonal
• Clone: 23C
• Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: P46100
• Gene Symbols: ATRX; RAD54L; XH2
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to the N-terminus of human ATRX.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Epigenetics and Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_000480
• Target Species: Human, Mouse
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only