MilliporeSigma™ Mouse anti-Betacellulin, Clone: 6G10.1,

Catalog No.	Quantity
MABS458MI	100 μg

Catalog No. MABS458MI Supplier MilliporeSigma™ Supplier No. MABS458

Description

Mouse Monoclonal Antibody

Specifically detects Betacellulin clone: 6G10.1 in Human samples, and it is validated for Immunohistochemistry, Western Blotting

The human BTC gene (Gene ID 685) encodes the 178 aa preprobetacellulin (UniProt P35070) protein. Post-translatioinal removal of the signal peptide (aa 1-31) produces probetacellulin (aa 32-178), which further matures into the 80 aa betacellulin (aa 32-111) following propeptide (aa 112-178) removal. Betacellulin is an EGF family growth factor with a higher affinity and specificity for ErbB1/EGFR and ErbB4. Betacellulin plays an important role in the development of the acute exacerbations of chronic obstructive pulmonary disease. Betacellulin is also reported to induce CXCL8 (IL-8) production from human lung cancer cells through EGFR–PI3K–Akt–ERK pathway activation, resulting in the recruitment of inflammatory cells in the cancer tissue and creating an inflammatory tumor microenvironment.

Specifications

• Antigen: Betacellulin
• Applications: Immunohistochemistry, Western Blot
• Classification: Monoclonal
• Clone: 6G10.1
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: P35070
• Gene Symbols: BTC
• Host Species: Mouse
• Immunogen: GST-tagged human recombinant full-length mature betacellulin.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001720
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only