MilliporeSigma Mouse anti-Bmi-1, Clone: F6, Alexa Fluor 488,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma 05637AF488
Specifically detects Bmi-1 clone: F6 in Human, Monkey samples, and it is validated for ImmunocytochemistryPolycomb complex protein BMI-1 (UniProt P25916; also known as B lymphoma Mo-MLV insertion region 1, Polycomb group RING finger protein 4) is encoded by the Bmi1 (also known as AW546694, Bmi-1, Pcgf4) gene (Gene ID 12151) in murine species. Bmi1 is a member of the polycomb group (PcG) family of evolutionarily conserved gene silencers involved in cell fate decisions and body pattern during development. Bmi1 is an important regulator of self-renewal of hematopoietic and neural stem cells, as well as cancer stem cells (CSCs). Bmi1 is a main constituent of the polycomb repressive complex 1 (PRC1) and pariticipates in PRC-mediated gene silencing by promoting monoubiquitination of H2A. Bmi1 overexpression is reported in many different human cancers and high level of Bmi1 is considered as a poor prognostic marker. Bmi1 targets genes involved in transforming growth factor-β/bone morphogenetic protein (TGF-beta/BMP), endoplasmic reticulum (ER) stress, and WNT pathways. Bmi itself is transcriptionally regulated by c-Myc and E2F1 transcription factors.
|Purified mouse conjugate antibody in PBS with 15mg/mL BSA and 0.1% sodium azide.|
|Epigenetics and Nuclear Function|
|Alexa Fluor 488|
|BMI1; PCGF4; RNF51|
|Recombinant Bmi-1 protein corresponding to residues 1-202 of mouse Bmi-1.|
|Protein G Purified|
|Stable for one year at 2°C to 8°C from date of receipt.|
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