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MilliporeSigma™ Mouse anti-BPTF, Clone: 15B1.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABE443

Catalog No. MABE443MI


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Description

Description

Specifically detects BPTF clone: 15B1.1 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Nucleosome-remodeling factor (NURF) subunit BPTF (UniProt E9Q6A7 & A2A654; also known as Bromodomain and PHD finger-containing transcription factor, Fetal Alzheimer antigen) is encoded by the Bptf (also known as 9430093H17Rik, Falz) gene (Gene ID 207165) in murine species. ATP-dependent chromatin remodeling complexes are classified into four major subfamilies (SWI/SNF, ISWI, CHD, and INO80). NURF is the founding member of ISWI remodeling complexes. Mammalian NURF is composed of BPTF, the ATPase SNF2L, and the Trp-Asp (WD) repeat protein pRBAP46/48, with BPTF being the largest subunit among the three. BPTF PHD finger-mediated binding of H3K4me3 stabilizes the NURF complex on chromatin, resulting in NURF-catalyzed nucleosome sliding. The NURF remodeling complex is essential for mammalian development and executes epigenetic regulation in multiple signaling pathways, including heat shock, TGF-beta/SMAD, JAK/STAT, WNT/beta-catenin, RB, and nuclear hormone receptors.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

BPTF
Monoclonal
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Bptf
GST-tagged recombinant protein corresponding to mouse BPTF.
100 μg
Epigenetics and Nuclear Function
NP_789820
Stable for one year at 2°C to 8°C from date of receipt.
IgG2b κ
Immunohistochemistry (Paraffin), Western Blot
15B1.1
E9Q6A7
Mouse
Protein G Purified
RUO
Primary
Human, Mouse, Rat
Purified
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