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MilliporeSigma™ Mouse anti-BPTF, Clone: 15B1.1,

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MABE443MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects BPTF clone: 15B1.1 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Nucleosome-remodeling factor (NURF) subunit BPTF (UniProt E9Q6A7 & A2A654; also known as Bromodomain and PHD finger-containing transcription factor, Fetal Alzheimer antigen) is encoded by the Bptf (also known as 9430093H17Rik, Falz) gene (Gene ID 207165) in murine species. ATP-dependent chromatin remodeling complexes are classified into four major subfamilies (SWI/SNF, ISWI, CHD, and INO80). NURF is the founding member of ISWI remodeling complexes. Mammalian NURF is composed of BPTF, the ATPase SNF2L, and the Trp-Asp (WD) repeat protein pRBAP46/48, with BPTF being the largest subunit among the three. BPTF PHD finger-mediated binding of H3K4me3 stabilizes the NURF complex on chromatin, resulting in NURF-catalyzed nucleosome sliding. The NURF remodeling complex is essential for mammalian development and executes epigenetic regulation in multiple signaling pathways, including heat shock, TGF-beta/SMAD, JAK/STAT, WNT/beta-catenin, RB, and nuclear hormone receptors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BPTF
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 15B1.1
Formulation Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. E9Q6A7
Gene Symbols Bptf
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to mouse BPTF.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics and Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_789820
Target Species Human, Mouse, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only

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