BRCA1 Mouse anti-Human, Monoclonal Antibody, Abnova™

Catalog No.	Quantity
89-112-713	100 μg

Catalog No. 89-112-713 Supplier Abnova Corporation Supplier No. MAB6119

Description

Mouse monoclonal antibody raised against partial recombinant BRCA1.

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq

Specifications

• Antigen: BRCA1
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant BRCA1.
• Dilution: Western Blot (1-10 ug/mL) Immunoprecipitation (1-10 ug/mL) Immunohistochemistry (1-10 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4
• Gene: BRCA1
• Gene Alias: BRCAI/BRCC1/IRIS/PSCP/RNF53
• Gene Symbols: BRCA1
• Host Species: Mouse
• Immunogen: Recombinant GST fusion protein corresponding to amino acids 762-1315 of human BRCA1.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 672
• Test Specificity: This antibody recognizes full-length BRCA1, a 220 kD nuclear phosphoprotein, and does not recognize the Deltaexon 11 splice variant.
• Target Species: Human
• Content And Storage: Store at -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1 κ