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Description
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq
Specifications
Specifications
| Antigen | BUB1B |
| Applications | ELISA, Immunofluorescence, Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Clone | 8G1 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against partial recombinant BUB1B. |
| Dilution | Western Blot (1:200-1:1000) Immunofluorescence (1:200-1:1000) The optimal working dilution should be determined by the end user. |
| Formulation | In 20mM KH2PO4, 150mM NaCl, pH 7.2 (0.01% sodium azide) |
| Gene | BUB1B |
| Gene Alias | BUB1beta/BUBR1/Bub1A/MAD3L/SSK1/hBUBR1 |
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