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Mouse anti-Calponin 1, Clone: CALP, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus BiologicalsSupplier Diversity Partner NBP2444790.1MG

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Catalog No. NBP24447901


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Description

Description

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

Calponin 1 Monoclonal antibody specifically detects Calponin 1 in Human, Rat samples. It is validated for Flow Cytometry, Immunohistochemistry-Paraffin, SDS-Page, Flow (Intracellular), Immunofluorescence.
Specifications

Specifications

Calponin 1
CALP
Unconjugated
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Purified
CNN1
Crude human uterus extract
34 kDa
0.1 mg
Cancer, Cytoskeleton Markers
Primary
1264
Human, Rat
Flow Cytometry, Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence
0.2mg/mL
Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 1 - 2 ug/ml
P51911
Basic calponin, calponin 1, basic, smooth muscle, Calponin H1, smooth muscle, calponins, basic, Sm-Calp, SMCCcalponin-1
Mouse
IgG1 Kappa
Protein A or G purified
RUO
Store at 4C.
Monoclonal
Multiple isoelectric variants of calponin have been identified, however only two molecular weight isoforms exist; a 34kDa form and a 29kDa form. Expression of the 29kDa form, I-calponin, is primarily restricted to muscle of the urogenital tract, whereas the higher molecular weight variant has been demonstrated in vascular and visceral smooth muscle. In Western blotting, this MAb reacts with only the 34kDa form of calponin in extracts of human aortic medial smooth muscle and is unreactive with fibroblast extracts of cultivated human foreskin. Calponin is a calmodulin, F-actin and tropomyosin binding protein, which is thought to be involved in the regulation of smooth muscle contraction. Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differentiated (contractile) phenotype of developing smooth muscle.
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