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MilliporeSigma™ Mouse anti-CASK, Clone: 2G5.1,

Catalog No. MABN1547MI Shop All MilliporeSigma Products
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MABN1547MI 100 μg
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Catalog No. MABN1547MI Supplier MilliporeSigma™ Supplier No. MABN1547
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Description

Mouse Monoclonal Antibody

Specifically detects CASK clone: 2G5.1 in Human, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting

Peripheral plasma membrane protein CASK (EC 2.7.11.1; UniProt O14936; also known as Calcium/calmodulin-dependent serine protein kinase, Membrane-associated guanylate kinase, hCASK, Protein lin-2 homolog, Trinucleotide repeat containing 8) is encoded by the CASK (also known as CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8) gene (Gene ID 8573) in human. CASK is a membrane-associated guanylate kinase (MAGUK) family member involved in the regulation of cytoskeletal remodeling and cell migration. It consists of a Ca2+-calmodulin kinase, a PDZ, an SH3, and a guanylate kinase domain. CASK localizes at cell–cell adhesion sites, including synaptic junctions, epithelial junctions, and tight junctions, where it is reported to associate with other cell adhesion molecules, such as junctional adhesion molecule (JAM), cadherins, catenins, and syndecan-2. CASK and syndecan-2 expressions are upregulated in colorectal cancer and their upregulation significantly correlates with advanced tumor stage, lymphatic invasion, lymph node metastasis, vascular invasion, liver metastasis, and unresectable metastatic CRC.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CASK
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2G5.1
Formulation Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. O14936
Gene Symbols CASK; LIN2
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to an internal fragment within the C-terminal half of human CASK.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_003679
Target Species Human, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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