CASP8, Mouse, Monoclonal Antibody, Abnova™

Catalog No.	Quantity
89-109-324	100 μg

Catalog No. 89-109-324 Supplier Abnova Corporation Supplier No. MAB11142

Description

Mouse monoclonal antibody raised against synthetic peptide of CASP8.

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq

Specifications

• Antigen: CASP8
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against synthetic peptide of CASP8.
• Dilution: ELISA (1:5000-1:20000) Western Blot (1:100-1:2000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (1% BSA, 50% glycerol, 0.02% sodium azide)
• Gene: CASP8
• Gene Alias: ALPS2B/CAP4/FLICE/FLJ17672/MACH/MCH5/MGC78473
• Gene Symbols: CASP8
• Host Species: Mouse
• Immunogen: A synthetic peptide corresponding to C-terminus of human CASP8.
• Purification Method: Protein G purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 841
• Target Species: Human
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid