CCND1, Mouse, Clone: CY-D1, Abnova™

Catalog No.	Quantity
89-110-436	100 μg

Catalog No. 89-110-436 Supplier Abnova Corporation Supplier No. MAB1449

Description

Mouse monoclonal antibody raised against full-length recombinant CCND1.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq

Specifications

• Antigen: CCND1
• Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Western Blot
• Classification: Monoclonal
• Clone: DCS-6
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against full length recombinant CCND1.
• Dilution: Western Blot (4 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (8 ug/mL) Immunohistochemistry (Frozen sections) (8 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: Lyophilized from 1.2% sodium acetate (2mg BSA, 0.01mg sodium azide)
• Gene: CCND1
• Gene Alias: BCL1/D11S287E/PRAD1/U21B31
• Gene Symbols: CCND1
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to full length human CCND1.
• Purification Method: Affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 595
• Target Species: Human
• Content And Storage: Store at -20°C on dry atmosphere. After reconstitution with 1mL of 1.2% sodium acetate or neutral PBS to a concentration of 100μg/mL store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Form: Lyophilized
• Isotype: IgG2a