CCND1, Mouse, Clone: DCS6, Abnova™

Catalog No.	Quantity
89-110-667	100 μg

Catalog No. 89-110-667 Supplier Abnova Corporation Supplier No. MAB1851

Description

Mouse monoclonal antibody raised against recombinant CCND1.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq

Specifications

• Antigen: CCND1
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: DCS6
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against recombinant CCND1.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.08% sodium azide)
• Gene: CCND1
• Gene Alias: BCL1/D11S287E/PRAD1/U21B31
• Gene Symbols: CCND1
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to human CCND1.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 595
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG2a