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CD107b Mouse anti-Human, PE, Clone: H4B4, BD

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BDB565306 50 Tests
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Catalog No. BDB565306 Supplier BD Biosciences Supplier No. 565306
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Description

Mouse Monoclonal Antibody

The H4B4 monoclonal antibody specifically binds to CD107b. CD107b is a heavily glycosylated, ∽120 kDa type I transmembrane protein that is also known as lysosomal-associated membrane protein 2 (LAMP-2/LAMP2), LAMPB, or LGP110. CD107b is expressed in the lysosomal and endosomal membranes of most cell types where it may play a role in maintaining membrane integrity. CD107b is also expressed on the surface of activated platelets and lymphocytes, including T lymphocytes, e.g., degranulating CD8+ cytotoxic T cells. CD107b serves as a ligand for selectins, including E-selectin, and mediates cellular adhesion. CD107a/ LAMP-1 and CD107b /LAMP-2 are carriers for poly-N-acetyllactosamines, and display the sialyl Le[x] antigen. CD107b is likewise expressed on some tumor cells and cell lines, including U937 and KG1a, and may facilitate tumor metastases.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD107b
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone H4B4
Conjugate PE
Description LAMP-2; LAMP2; LAMPB; LGP110
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Human Adult Adherent Peripheral Blood Cells
Purification Method Affinity Purified
Quantity 50 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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