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CD117 Mouse anti-Human, APC-R700, Clone: YB5.B8, BD

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BDB565195 100 Tests
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Catalog No. BDB565195 Supplier BD Biosciences Supplier No. 565195
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Description

Mouse Monoclonal Antibody

The YB5.B8 monoclonal antibody specifically binds to CD117, which is also known as c-Kit, or Stem cell factor Receptor (SCFR). CD117 is a ∽145 kDa type I transmembrane glycoprotein with tyrosine kinase activity. CD117 is present on hematopoietic progenitor cell subsets, thymocytes, mast cells, hepatocytes and histiocytes. CD117 serves as a cytokine receptor for steel factor (SLF), also known as stem cell factor (SCF), or mast cell growth factor (MGF). The interaction of CD117 and SLF is crucial to hematopoiesis, mast cell differentiation, melanogenesis, and germ cell development. The ability of the YB5.B8 antibody to block the binding of c-Kit ligand is still controversial.

This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700. APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45-nm filter).

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD117
Applications Flow Cytometry
Classification Monoclonal
Clone YB5.B8
Conjugate APC-R700
Description KIT; c-Kit; SCFR; PBT; Mast/stem cell growth factor receptor
Formulation Aqueous buffered solution containing BSA, protein stabilizer, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Acute myelocytic leukemia blasts
Purification Method Affinity Purified
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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