CD209, Mouse, Clone: 8B6, Abnova™

Catalog No.	Quantity
89-111-121	100 μg

Catalog No. 89-111-121 Supplier Abnova Corporation Supplier No. MAB2749

Description

Mouse monoclonal antibody raised against recombinant CD209.

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants

Specifications

• Antigen: CD209
• Applications: Immunohistochemistry, Western Blot
• Classification: Monoclonal
• Clone: 8B6
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against recombinant CD209.
• Dilution: Western Blot (1-2 mg/mL) Immunohistochemistry (5-10 mg/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.02% sodium azide)
• Gene: CD209
• Gene Alias: CDSIGN/CLEC4L/DC-SIGN/DC-SIGN1/MGC129965
• Gene Symbols: CD209
• Host Species: Mouse
• Immunogen: Recombinant His fusion protein corresponding to extracellular region of human CD209.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 30835
• Target Species: Human
• Content And Storage: Store at 4°C for three months. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG