CD226, Mouse, Clone: DX11, Abnova™

Mouse monoclonal antibody raised against native CD226.

Supplier:  Abnova Corporation MAB5270

Catalog No. 89-112-199

Description

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq

Specifications

• Antigen: CD226
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Flow Cytometry (10ul of the suggested working dilution (1:25-1:100) to label 1x 10⁶ cells in 100ul) The optimal working dilution should be determined by the end user.
• Gene: CD226
• Gene Symbols: CD226
• Immunogen: Native purified CD226 from human cytotoxic T lymphocyte clone.
• Regulatory Status: RUO
• Gene ID (Entrez): 10666
• Target Species: Human
• Form: Liquid

• Applications: Flow Cytometry, Immunoprecipitation
• Clone: DX11
• Description: Mouse monoclonal antibody raised against native CD226.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: DNAM-1/DNAM1/PTA1/TLiSA1
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibdoy recognizes human CD226, a 65kD glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes. Clone DX11 is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells (3).
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1