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CD27, Mouse, Clone: CLB-27, Abnova™

Catalog No. 89112192 Shop All Abnova Corporation Products
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89-112-192 1 mL
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Catalog No. 89-112-192 Supplier Abnova Corporation Supplier No. MAB5255

Description

Mouse monoclonal antibody raised against native CD27.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq

Specifications

Antigen CD27
Applications Flow Cytometry, Immunofluorescence
Classification Monoclonal
Clone CLB-27
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against native CD27.
Dilution The optimal working dilution should be determined by the end user.
Formulation In 20mM Tris, 150mM NaCl, pH 8.0 (10mg BSA, 0.001% thimerosal)
Gene CD27
Gene Alias MGC20393/S152/T14/TNFRSF7/Tp55
Gene Symbols CD27
Host Species Mouse
Immunogen Native purified CD27 from human E-rossette positive lymphocytes.
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 939
Test Specificity The monoclonal antibody is directed against the CD27 antigen, a 55 kD protein, which is expressed on a large subpopulation (75%) of peripheral blood T-lymphocytes and most medullary thymocytes. Little binding was observed with normal human B-cells, CD3 negative leukemic cells, B-cells derived and myeloid leukemias.
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG2a
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