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MilliporeSigma™ Mouse anti-CD3, Clone: SK7, PE,

Catalog No. MABF1735 Shop All MilliporeSigma Products
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MABF1734 25 Tests
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Description

Mouse Monoclonal Antibody

Specifically detects CD3 clone: SK7 in Human samples, and it is validated for Flow Cytometry

The SK7 antibody is specific for human CD3e, also known as CD3 epsilon, a 20kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.The SK7 antibody is a widely used phenotypic marker for human T cells. This antibody may induce T cell activation in the presence of monocytes. The antibody has also been demonstrated to be cross-reactive with Chimpanzee CD3. Binding of clone SK7 can be blocked by an alternative Anti-Human CD3 clone, OKT3. Please choose the appropriate format for each application.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD3
Applications Flow Cytometry
Classification Monoclonal
Clone SK7
Conjugate PE
Formulation Purified Mouse monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Accession No. P07766
Gene Symbols CD3E; T3E
Host Species Mouse
Immunogen Immunogen information for this antibody is proprietary information.
Purification Method Purified by size-exclusion chromatography
Quantity 100 Tests
Regulatory Status RUO
Research Discipline Inflammation and Immunology
Primary or Secondary Primary
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt. Note: It is recommended to store the product undiluted at 2°C to 8°C and protected from prolonged exposure to light. Do not freeze.
Form Purified
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For Research Use Only

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