CD369 Mouse anti-Human, Alexa Fluor 647, Clone: 15E2, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 564855

Catalog No. BDB564855

Description

The 15E2 monoclonal antibody specifically binds to CD369 which is also known as CLEC7A (C-type lectin domain family 7 member A), Dectin-1 (Dendritic cell-associated C-type lectin 1), or BGR (Beta-glucan receptor). CD369 is a type II transmembrane C-type lectin that contains a C-terminal stalk with a carbohydrate recognition domain (CRD) in the extracellular domain, a transmembrane segment, and an ITAM containing cytoplasmic tail. This protein is highly expressed on dendritic cells. It is also expressed on B cells, monocytes, eosinophils, mast cells, macrophages, endothelial cells, and is lowly expressed on some subsets of T cells. CD369 binds to beta-glucan polymers and functions as a pattern recognition receptor in innate immune response to fungal and bacterial pathogens. The 15E2 antibody can reportedly stimulate dendritic cells to costimulate immune responses.

Specifications

• Antigen: CD369
• Classification: Monoclonal
• Conjugate: Alexa Fluor 647
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: Human Dectin-1 Recombinant Protein
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

• Applications: Flow Cytometry
• Clone: 1.50E+03
• Description: CLEC7A; CLC7A; BGR; CLECSF12; CANDF4
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2a κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov