MilliporeSigma™ Mouse anti-CD37, Clone: MB-1,

Catalog No.	Quantity
MABF913	100 μg

Catalog No. MABF913 Supplier MilliporeSigma™ Supplier No. MABF913

Description

Mouse Monoclonal Antibody

Specifically detects CD37 clone: MB-1 in Human samples, and it is validated for Flow Cytometry, Immunohistochemistry, Immunoprecipitation

Leukocyte antigen CD37 (UniProt P11049; also known as CD37, Tetraspanin-26, Tspan-26) is encoded by the CD37 (also known as TSPAN26) gene (Gene ID 951) in human. CD37 is a 4-transmembrane (a.a. 18-38, 60-74, 86-111, 242-266) tetraspanin superfamily member with both its N- and C-terminal ends exposed cytoplasmically (a.a. 1-17, 267-281). While most tetraspanins are ubiquitously expressed, CD37 is predominently expressed on antigen-presenting cells, with highest expression on B lymphocytes. CD37 is essential for B cell survival and Cd37-/- mice showed greatly reduced IgG-secreting plasma cells in lymphoid organs due to increased apoptosis in the spleen germinal centers, where B cells proliferate. On the other hand, CD37 is also found to play a negative role against T cell proliferation, macrophages interleukin-6 production, and dendritic cells (DCs) antigen presentation.

Specifications

• Antigen: CD37
• Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
• Classification: Monoclonal
• Clone: MB-1
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: P11049
• Gene Symbols: CD37; TSPAN26
• Host Species: Mouse
• Immunogen: Lymph node cells from a lymphoma patient.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Inflammation and Immunology
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001765.1
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only