CD40, Mouse, Clone: BE-1, Abnova™

Catalog No.	Quantity
89-113-058	100 μg

Catalog No. 89-113-058 Supplier Abnova Corporation Supplier No. MAB6911

Description

Mouse monoclonal antibody raised against native CD40.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

• Antigen: CD40
• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
• Classification: Monoclonal
• Clone: BE-1
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against native CD40.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In 50mM sodium phosphate buffer, 100mM potassium chloride, 150mM NaCl, pH 7.5 (0.5mg/mL gentamicin sulfate)
• Gene: CD40
• Gene Alias: Bp50/CDW40/MGC9013/TNFRSF5/p50
• Gene Symbols: CD40
• Host Species: Mouse
• Immunogen: Native purified CD40 from murine L cells.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 958
• Test Specificity: This antibody binds with cross linked BE-1 will partially activate B cells.
• Target Species: Human
• Content And Storage: Store at 4°C.
• Form: Liquid
• Isotype: IgG1