CD40, Mouse, Clone: HI40a, Abnova™

Mouse monoclonal antibody raised against CD40.

Supplier:  Abnova Corporation MAB6446

Catalog No. 89-112-871

Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

• Antigen: CD40
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Flow Cytometry (0.25 mg/test) The optimal working dilution should be determined by the end user.
• Gene: CD40
• Gene Symbols: CD40
• Immunogen: Human CD40.
• Regulatory Status: RUO
• Gene ID (Entrez): 958
• Target Species: Human
• Form: Liquid

• Applications: Flow Cytometry
• Clone: HI40a
• Description: Mouse monoclonal antibody raised against CD40.
• Formulation: In PBS, 300mM NaCl, pH 7.4
• Gene Alias: Bp50/CDW40/MGC9013/TNFRSF5/p50
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: This antibody recognizes CD40 (BP50), a 48 KDa type I single chain transmembraneglycoprotein expressed on normal and neoplastic B cells, but not on terminally differentiatedplasma cells.
• Content And Storage: Store at 4°C. Do not freeze.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG1