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CD40, Mouse, Clone: HI40a, Abnova™

Catalog No. 89112871 Shop All Abnova Corporation Products
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89-112-871 100 μg
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Catalog No. 89-112-871 Supplier Abnova Corporation Supplier No. MAB6446
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Description

Mouse monoclonal antibody raised against CD40.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

Antigen CD40
Applications Flow Cytometry
Classification Monoclonal
Clone HI40a
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against CD40.
Dilution Flow Cytometry (0.25 mg/test) The optimal working dilution should be determined by the end user.
Formulation In PBS, 300mM NaCl, pH 7.4
Gene CD40
Gene Alias Bp50/CDW40/MGC9013/TNFRSF5/p50
Gene Symbols CD40
Host Species Mouse
Immunogen Human CD40.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 958
Test Specificity This antibody recognizes CD40 (BP50), a 48 KDa type I single chain transmembraneglycoprotein expressed on normal and neoplastic B cells, but not on terminally differentiatedplasma cells.
Target Species Human
Content And Storage Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1
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