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CD40a, Mouse, FITC, Clone: HI40a, Abnova™

Catalog No. 89112101 Shop All Abnova Corporation Products
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100 Reactions
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89-112-101 100 Reactions
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Catalog No. 89-112-101 Supplier Abnova Corporation Supplier No. MAB5079
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Description

Mouse monoclonal antibody raised against CD40a.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Specifications

Antigen CD40a
Applications Flow Cytometry
Classification Monoclonal
Clone HI40a
Conjugate FITC
Description Mouse monoclonal antibody raised against CD40a.
Dilution Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.2% BSA, 0.09% sodium azide)
Gene CD40
Gene Alias Bp50/CDW40/MGC9013/TNFRSF5/p50
Gene Symbols CD40
Host Species Mouse
Immunogen Human CD40a.
Quantity 100 Reactions
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 958
Test Specificity This antibody recognizes CD40 (BP50), a 48 KDa type I single chain transmembrane glycoprotein expressed on normal and neoplastic B cells, but not on terminally differentiated plasma cells.
Target Species Human
Content And Storage Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1
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