CD44, Mouse, Clone: DF 1485, Abnova™

Catalog No.	Quantity
89-112-218	1 mL

Catalog No. 89-112-218 Supplier Abnova Corporation Supplier No. MAB5315

Description

Mouse monoclonal antibody raised against native CD44.

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq

Specifications

• Antigen: CD44
• Applications: Immunohistochemistry, Immunohistochemistry (Frozen)
• Classification: Monoclonal
• Clone: DF 1485
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against native CD44.
• Dilution: Immunohistochemistry (1:5-1:10) The optimal working dilution should be determined by the end user.
• Formulation: In tissue culture supernatant
• Gene: CD44
• Gene Alias: CDW44/CSPG8/ECMR-III/HCELL/IN/LHR/MC56/MDU2/MDU3/MGC10468/MIC4/MUTCH-I/Pgp1
• Gene Symbols: CD44
• Host Species: Mouse
• Immunogen: Native purified human CD44.
• Quantity: 1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 960
• Test Specificity: HCAM, CD44 is a transmembrane glycoprotein which is expressed by lymphocytes and several normal epithelial cells. The CD44 molecule is involved in lymphocyte homing, T-lymphocyte actvitation, interaction with hyaluronic acid and may act as an adhesion molecule. Standard CD 44 (CD44s) is composed of the products of exons 1-5 a less favourable prognosis in gastrointestinal cancers, the loss of CD44s expression predicts unfavourable outcome in bladder cancers, squamous cell carcinomas of the skin, prostatic adenocarcinomas and neuroblastomas. In immunoblotting this antibody reacts with a glycoprotein isolated from hemopoietic cells and epithelials cells with a respective molecular weight of 29-37 and 51 kD.
• Target Species: Human
• Content And Storage: Store at 4°C.
• Form: Liquid
• Isotype: IgG1