CD45RA, Mouse, APC, Clone: MEM-56, Abnova™

Mouse monoclonal antibody raised against native CD45RA.

Supplier:  Abnova Corporation MAB4624

Catalog No. 89-111-939

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq

Specifications

• Antigen: CD45RA
• Classification: Monoclonal
• Conjugate: APC
• Dilution: Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 10⁶ cells in a suspension) The optimal working dilution should be determined by the end user.
• Gene: PTPRC
• Gene Symbols: PTPRC
• Immunogen: Native purified CD45RA from human thymocytes and T lymphocytes.
• Regulatory Status: RUO
• Gene ID (Entrez): 5788
• Target Species: Human
• Form: Liquid

• Applications: Flow Cytometry
• Clone: MEM-56
• Description: Mouse monoclonal antibody raised against native CD45RA.
• Formulation: In PBS (0.2% BSA, 0.09% sodium azide)
• Gene Alias: B220/CD45/CD45R/GP180/LCA/LY5/T200
• Host Species: Mouse
• Quantity: 100 Reactions
• Primary or Secondary: Primary
• Test Specificity: This antibody reacts with CD45RA, a 205-220 KDa single chain type I glycoprotein, variant of CD45 (CD45RA isoform). CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes.
• Content And Storage: Store in the dark at 4°C. Do not freeze.
  Avoid prolonged exposure to light.
  Aliquot to avoid repeated freezing and thawing.
• Isotype: IgG2b