CD45RA (PTPRC), Mouse, Clone: 158-4D3, Abnova™

Catalog No.	Quantity
89-109-462	100 μg

Catalog No. 89-109-462 Supplier Abnova Corporation Supplier No. MAB11299

Description

Mouse monoclonal antibody raised against CD45RA (PTPRC).

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq

Specifications

• Antigen: CD45RA (PTPRC)
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Immunoprecipitation
• Classification: Monoclonal
• Clone: 158-4D3
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against CD45RA (PTPRC).
• Dilution: Flow Cytometry (1 ug/10⁶ cells) Immunocytochemistry/Immunofluorescence (1:10-1:2000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500) Immunoprecipitation (1:10-1:500) The optimal working dilution should b
• Formulation: In PBS (0.05% BSA, 0.05% sodium azide)
• Gene: PTPRC
• Gene Alias: B220/CD45/CD45R/GP180/LCA/LY5/T200
• Gene Symbols: PTPRC
• Host Species: Mouse
• Immunogen: Stimulated human leukocytes.
• Purification Method: Protein G purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5788
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG2a κ