CD53, Mouse, FITC, Clone: MEM-53, Abnova™

Catalog No.	Quantity
89-111-949	100 Reactions

Catalog No. 89-111-949 Supplier Abnova Corporation Supplier No. MAB4639

Description

Mouse monoclonal antibody raised against native CD53.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq

Specifications

• Antigen: CD53
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: MEM-53
• Conjugate: FITC
• Description: Mouse monoclonal antibody raised against native CD53.
• Dilution: Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 10⁶ cells in a suspension) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.2% BSA, 0.09% sodium azide)
• Gene: CD53
• Gene Alias: MOX44/TSPAN25
• Gene Symbols: CD53
• Host Species: Mouse
• Immunogen: Native purified CD53 from leukocytes of patient suffering from LGL-type leukaemia.
• Quantity: 100 Reactions
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 963
• Test Specificity: This antibody reacts with CD53, a 32-40 KDa tetraspanin family glycoprotein exclusivelly expressed on leukocytes; it is not present on platelets, red blood cells and non-hematopoietic cells. This antibody reacts also with deglycosylated molecule (molecular weight of the antigen is reduced by 15 KDa using endoglycosidase F).
• Target Species: Human
• Content And Storage: Store in the dark at 4°C. Do not freeze.
  Avoid prolonged exposure to light.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1