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  6. CD56 Mouse anti-Human, APC-R700, Clone: NCAM16.2, BD

CD56 Mouse anti-Human, APC-R700, Clone: NCAM16.2, BD

Catalog No. BDB565140 Shop All BD Biosciences Products
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BDB565139 100 Tests
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Catalog No. BDB565140 Supplier BD Biosciences Supplier No. 565140
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Description

Mouse Monoclonal Antibody

The NCAM16.2 monoclonal antibody specifically binds to human CD56. It recognizes an extracellular immunoglobulin-like domain common to 120, 140, and 180 kDa forms of CD56, also known as the neural cell adhesion molecule (NCAM), NKH1 or MSK39. The CD56 antigen is expressed on approximately 10% to 25% of peripheral blood lymphocytes. It is present on essentially all resting and activated CD16+ natural killer (NK) lymphocytes and approximately 5% of CD3+ peripheral blood lymphocytes. CD3+ CD56+ T lymphocytes comprise a unique subset of cytotoxic T lymphocytes that mediates non-major histocompatibility complex (MHC)-restricted cytotoxicity. CD56 antigen density on NK lymphocytes increases upon cellular activation. The CD56 antigen is involved in neuronal homotypic cell adhesion and cell differentiation during embryogenesis. CD16+ CD56+ NK cells demonstrate reciprocal transfer of an activation state with dendritic cells.

This antibody was conjugated to BD Horizon APC-R700, which has been developed exclusively by BD Biosciences as a better alternative to Alexa Fluor™ 700. APC-R700 excites and emits at similar wavelengths to Alexa Fluor™ 700 yet exhibits significantly improved brightness. This dye can be excited by the red laser and detected with the same filter set as Alexa Fluor™ (eg, 730/45-nm filter).

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD56
Applications Flow Cytometry
Classification Monoclonal
Clone NCAM16.2
Conjugate APC-R700
Description NCAM1; NCAM-1; NCAM; Leu-19; Neural cell adhesion molecule 1; NKH1; MSK39
Formulation Aqueous buffered solution containing BSA, protein stabilizer, glycerol, and ≤0.09% sodium azide.
Host Species Mouse
Immunogen Immunoaffinity-enriched adult human brain NCAM
Purification Method Affinity Purified
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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