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CD59, Mouse, Biotin, Clone: MEM-43, Abnova™

Catalog No. 89112054 Shop All Abnova Corporation Products
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89-112-054 100 μg
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Catalog No. 89-112-054 Supplier Abnova Corporation Supplier No. MAB5009
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Description

Mouse monoclonal antibody raised against native CD59.

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq

Specifications

Antigen CD59
Applications Flow Cytometry
Classification Monoclonal
Clone MEM-43
Conjugate Biotin
Description Mouse monoclonal antibody raised against native CD59.
Dilution Flow Cytometry (1:40) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.4 (0.09% sodium azide)
Gene CD59
Gene Alias 16.3A5/1F5/EJ16/EJ30/EL32/FLJ38134/FLJ92039/G344/HRF-20/HRF20/MAC-IP/MACIF/MEM43/MGC2354/MIC11/MIN1/MIN2/MIN3/MIRL/MSK21/p18-20
Gene Symbols CD59
Host Species Mouse
Immunogen Native purified CD59 from thymocytes and T lymphocytes.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 966
Test Specificity This antibody reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 KDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues.
Target Species Human
Content And Storage Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG2a
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