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CD81 Mouse anti-Human, PerCP-Cy5.5, Clone: JS-81, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 565430

Catalog No. BDB565430


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Description

Description

The JS-81 monoclonal antibody specifically binds to CD81, which is also known as, Target of the antiproliferative antibody 1 (TAPA1, TAPA-1), or Tetraspanin-28 (Tspan-28/TSPAN28). CD81 is an ~26 kDa transmembrane protein that belongs to the tetraspanin (TM4SF) family. It is involved in cell growth and signal transduction. CD81 has a very broad cellular distribution, being expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. In hematopoietic cells, the CD81 antigen is expressed on B and T lymphocytes, NK cells, thymocytes, eosinophils, germinal center follicular dendritic cells, and to a variable extent on monocytes. The CD81 antigen is not expressed on neutrophils, platelets, or erythrocytes. CD81-specific antibodies have been shown to have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas. They are also reported to induce homotypic cell aggregation. Immunoprecipitation studies reveal that CD81 is a component of a multimolecular complex of CD19, CD21, and CD225 that is involved in the activation and control of B cell growth.

Specifications

Specifications

CD81
JS-81
TAPA1; Tetraspanin-28; Tspan-28; TSPAN28; CVID6; S5.7; M38
Affinity Purified
IgG1, κ
100 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
PerCP-Cyanine5.5
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
Affinity Chromatography
RUO
Primary
Canine, Human, Rabbit
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