CD86, Mouse, PE, Clone: BU63, Abnova™

Catalog No.	Quantity
89-111-841	100 Reactions

Catalog No. 89-111-841 Supplier Abnova Corporation Supplier No. MAB4469

Description

Mouse monoclonal antibody raised against native CD86.

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq

Specifications

• Antigen: CD86
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: BU63
• Conjugate: PE
• Description: Mouse monoclonal antibody raised against native CD86.
• Dilution: Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 10⁶ cells in a suspension) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.2% BSA, 0.09% sodium azide)
• Gene: CD86
• Gene Alias: B7-2/B70/CD28LG2/LAB72/MGC34413
• Gene Symbols: CD86
• Host Species: Mouse
• Immunogen: Native purified CD86 from human ARH-77 cell.
• Quantity: 100 Reactions
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 942
• Test Specificity: This antibody reacts with CD86 (B7-2), a 70 KDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
• Target Species: Human
• Content And Storage: Store in the dark at 4°C. Do not freeze.
  Avoid prolonged exposure to light.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1