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CDH1, Mouse, APC, Clone: 67A4, Abnova™

Catalog No. 89113813 Shop All Abnova Corporation Products
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89-113-813 100 Reactions
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Catalog No. 89-113-813 Supplier Abnova Corporation Supplier No. MAB9850
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Description

Mouse monoclonal antibody raised against CDH1.

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq

Specifications

Antigen CDH1
Applications Flow Cytometry
Classification Monoclonal
Clone 67A4
Conjugate APC
Description Mouse monoclonal antibody raised against CDH1.
Dilution Flow Cytometry (10 uL reagent/100 uL of whole blood or 106 cells) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.4 (0.02% BSA, 0.09% sodium azide)
Gene CDH1
Gene Alias Arc-1/CD324/CDHE/ECAD/LCAM/UVO
Gene Symbols CDH1
Host Species Mouse
Immunogen Human ductal breast epithelial tumor, T-47D cells.
Purification Method Size-exclusion chromatography purification
Quantity 100 Reactions
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 999
Test Specificity The mouse monoclonal antibody 67A4 recognizes CDH1 (CD324), an approximately 100 kDa epithelial cell adhesion molecule, whose detection is important for determination of invasive potential of epithelial neoplasms.
Target Species Human
Content And Storage Store in the dark at 4°C. Avoid prolonged exposure to light. Do not freeze.
Form Liquid
Isotype IgG1
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