MilliporeSigma™ Mouse anti-CDKL5, Clone: 8F3.1,

Catalog No.	Quantity
MABS1132	100 μg

Catalog No. MABS1132 Supplier MilliporeSigma™ Supplier No. MABS1132

Description

Mouse Monoclonal Antibody

Specifically detects CDKL5 clone: 8F3.1 in Mouse, Rat samples, and it is validated for Western Blotting

Cyclin-dependent kinase-like 5 (EC 2.7.11.22; UniProt O76039; also known as Serine/threonine-protein kinase 9) is encoded by the CDKL5 (also known as EIEE2, STK9) gene (Gene ID 6792) in human. CDKL5/STK9 is a serine/threonine protein kinase widely distributed in all tissues, with highest levels in thymus, testes, and brain, where it is found localized in the nucleus and dendrite of neurons. CDKL5/STK9 expression is found peaked in the early postnatal period and Cdkl5-knockdown in mice leads to autistic-like behavior, dendritic hypotrophy and impairment of neural circuit communication. Likewise, human CDKL5 gene mutations are linked to X-linked neurological developmental disorders involving severe mental retardation and seizures appearing in the first postnatal months. Point mutations in CDKL5 have also been reported in patients with atypical variants of Rett syndrome (RTT), infantile spasms and severe neurodevelopmental retardation.

Specifications

• Antigen: CDKL5
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 8F3.1
• Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: O76039
• Gene Symbols: CDKL5; EIEE2; STK9
• Host Species: Mouse
• Immunogen: GST-tagged recombinant human CDKL5 internal fragment.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001032420
• Target Species: Mouse, Rat
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only