CDKN1A, Mouse, Clone: DCS-60.2, Abnova™

Catalog No.	Quantity
89-108-948	1 mL

Catalog No. 89-108-948 Supplier Abnova Corporation Supplier No. MAB10747

Description

Mouse monoclonal antibody raised against CDKN1A.

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq

Specifications

• Antigen: CDKN1A
• Applications: Immunohistochemistry
• Classification: Monoclonal
• Clone: DCS-60.2
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against CDKN1A.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (protein base, 0.09% sodium azide)
• Gene: CDKN1A
• Gene Alias: CAP20/CDKN1/CIP1/MDA-6/P21/SDI1/WAF1/p21CIP1
• Gene Symbols: CDKN1A
• Host Species: Mouse
• Immunogen: CDKN1A.
• Quantity: 1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1026
• Target Species: Human
• Content And Storage: Store at 4°C is stable for 3 years.
• Form: Liquid
• Isotype: IgG2a