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MilliporeSigma™ Mouse anti-CENP-C, Clone: AL61A,

Catalog No. MABE1114 Shop All MilliporeSigma Products
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MABE1114 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects CENP-C clone: AL61A in Human samples, and it is validated for Immunocytochemistry, Immunoprecipitation

Centromere protein C (UniProt Q03188; also known as CENP-C, CENP-C 1, Centromere autoantigen C, Centromere protein C 1, Interphase centromere complex protein 7) is encoded by the CENPC (also known as CENPC1, ICEN7) gene (Gene ID 1060) in human. Kinetochores assemble on centromeres to bind spindle microtubules and mediate chromosome segregation during cell division. CENP-C is a subunit of constitutive centromere-associated network (CCAN) that acts as the centromere-kinetochore interface. CCAN is a large complex composed of at least 16 different centromeric proteins (CENPs). CENP-C plays an important role in kinetochore assembly downstream of CENP-A. The PEST domain in the N-terminal half of CENP-C interacts directly with the CCAN subcomplex CENP-HIKM (CENP-H, CENP-K, CENP-I, and CENP-M) and CENP-C depletion is shown to casue mislocalization of CENP-T and the CENP-HIKM complex subunits in HeLa cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CENP-C
Applications Immunocytochemistry, Immunoprecipitation
Classification Monoclonal
Clone AL61A
Formulation Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q03188
Gene Symbols CENPC; CENPC1; ICEN7
Host Species Mouse
Immunogen GST-tagged recombinant human CENP-C N-terminal fragment.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics and Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_001803
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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