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Description
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. [provided by RefSeq
Specifications
Specifications
| Antigen | CENPJ |
| Applications | ELISA, Western Blot |
| Classification | Monoclonal |
| Clone | 5D5 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against a partial recombinant CENPJ. |
| Formulation | ascites with no preservative |
| Gene | CENPJ |
| Gene Accession No. | NM_018451 |
| Gene Alias | BM032/CPAP/LAP/LIP1/MCPH6/MGC131581/MGC131582/MGC142222/MGC142224 |
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