CFI, Mouse, Clone: KT22, Abnova™

Catalog No.	Quantity
89-110-565	100 μg

Catalog No. 89-110-565 Supplier Abnova Corporation Supplier No. MAB1669

Description

Mouse monoclonal antibody raised against native CFI.

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq

Specifications

• Antigen: CFI
• Applications: ELISA
• Classification: Monoclonal
• Clone: KT22
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against native CFI.
• Dilution: ELISA (1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: CFI
• Gene Alias: C3B-INA/FI/IF/KAF
• Gene Symbols: CFI
• Host Species: Mouse
• Immunogen: Native Purified human CFI.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3426
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG2b