MilliporeSigma™ Mouse anti-CHUK, Clone: 3G12H9,

Catalog No.	Quantity
MABE628MI	100 μL

Catalog No. MABE628MI Supplier MilliporeSigma™ Supplier No. MABE628

Description

Mouse Monoclonal Antibody

Specifically detects CHUK clone: 3G12H9 in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting

Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK), also known as, IKK-alpha (I-Kappa-B kinase-alpha), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. CHUK plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. Mutation in CHUK has been associated with Cocoon syndrome.

Specifications

• Antigen: CHUK
• Applications: Immunocytochemistry, Western Blot
• Classification: Monoclonal
• Clone: 3G12H9
• Formulation: Mouse monoclonal IgG1 ascitic fluid containing 0.03% sodium azide.
• Gene Accession No.: O15111
• Gene Symbols: CHUK; IKKA; TCF16
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human CHUK expressed in E. coli.
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Epigenetics and Nuclear Function
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
• Form: Ascites
• Isotype: IgG1

For Research Use Only