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Citrullinated Fibrinogen, Mouse, Clone: 3D1, Abnova™

Catalog No. 89135931 Shop All Abnova Corporation Products
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100 μg
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89-135-931 100 μg
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Catalog No. 89-135-931 Supplier Abnova Corporation Supplier No. MAB5303
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Description

Mouse monoclonal antibody raised against synthetic peptide of Citrullinated Fibrinogen.

Specifications

Antigen Citrullinated Fibrinogen
Applications ELISA
Classification Monoclonal
Clone 3D1
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against synthetic peptide of Citrullinated Fibrinogen.
Dilution The optimal working dilution should be determined by the end user.
Formulation Lyophilized from 10mM ammonium bicarbonate buffer
Host Species Mouse
Immunogen A synthetic peptide corresponding to mouse Citrullinated Fibrinogen.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Fibrinogen is a protein produced by the liver which helps stop bleeding by helping blood clots to form. Fibrinogen gets deiminated (conversion from arginin to citrullin) by Peptidyl Arginine Deiminase (PAD) in inflamed joints in patients that develop rheumatoid arthritis. Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain citrulline. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin can get deiminated during cell death and tissue inflammation. Patients with rheumatoid arthritis often (at least 80% of them) develop an immune response against proteins containing citrulline.
Target Species Mouse
Content And Storage Store at 4°C on dry atmosphere. After reconstitution with deionized water store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Form Lyophilized
Isotype IgG1
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