COL1A2, Mouse, Clone: 2A3, Abnova™

Mouse monoclonal antibody raised against native COL1A2.

Supplier:  Abnova Corporation MAB5600

Catalog No. 89-112-309

Description

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish

Specifications

• Antigen: COL1A2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (2 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: COL1A2
• Gene Symbols: COL1A2
• Immunogen: Native human COL1A2.
• Regulatory Status: RUO
• Gene ID (Entrez): 1278
• Target Species: Human
• Form: Liquid

• Applications: Immunohistochemistry (Frozen)
• Clone: 2A3
• Description: Mouse monoclonal antibody raised against native COL1A2.
• Formulation: In 100mM BBS, pH 8.2
• Gene Alias: OI4
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Test Specificity: Reacts with human Type I collagen.
• Content And Storage: Store at 4°C.
• Isotype: IgG2b