MilliporeSigma™ Mouse anti-CRTC1, Clone: 5F3.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABE461

Catalog No. MABE461MI

Description

Specifically detects CRTC1 clone: 5F3.1 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry, Immunoprecipitation, Western Blotting

CREB-regulated transcription coactivator 1 (UniProt Q6UUV9; also known as Mucoepidermoid carcinoma translocated protein 1, TORC-1, Transducer of CREB protein 1, Transducer of regulated cAMP response element-binding protein 1) is encoded by the CRTC1 (also known as KIAA0616, MECT1, TORC1, WAMTP1) gene (Gene ID 23373) in human. CRTC1 belongs to a family of glycosylated Ser/Thr-rich phosphoproteins that bind the basic leucine zipper (bZIP) region of Ca²⁺/cAMP-responsive element-binding protein (CREB) and function as CREB coactivators. CRTCs participate in CREB-mediated transcriptions of both canonical cellular cAMP response elements (CREs) and the non-canonical viral CREs. CRTC1, specifically, is involved in CREB-mediated transcription of various neuronal immediate early genes (IEGs) as well as CREB-dependent hepatitis B virus (HBV) replication.

Specifications

• Antigen: CRTC1
• Classification: Monoclonal
• Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: CRTC1; KIAA0616; MECT1; TORC1; WAMTP1
• Immunogen: GST-tagged recombinant protein corresponding to human CRTC1/TORC-1 sequence within the N-terminal half..
• Quantity: 100 μg
• Research Discipline: Epigenetics and Nuclear Function
• Gene ID (Entrez): NP_001091952
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG2a κ

• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Clone: 5F3.1
• Gene Accession No.: Q6UUV9
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Purified

For Research Use Only