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MilliporeSigma™ Mouse anti-CRTC1, Clone: 5F3.1,

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MABE461MI 100 μg
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Description

Mouse Monoclonal Antibody

Specifically detects CRTC1 clone: 5F3.1 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry, Immunoprecipitation, Western Blotting

CREB-regulated transcription coactivator 1 (UniProt Q6UUV9; also known as Mucoepidermoid carcinoma translocated protein 1, TORC-1, Transducer of CREB protein 1, Transducer of regulated cAMP response element-binding protein 1) is encoded by the CRTC1 (also known as KIAA0616, MECT1, TORC1, WAMTP1) gene (Gene ID 23373) in human. CRTC1 belongs to a family of glycosylated Ser/Thr-rich phosphoproteins that bind the basic leucine zipper (bZIP) region of Ca2+/cAMP-responsive element-binding protein (CREB) and function as CREB coactivators. CRTCs participate in CREB-mediated transcriptions of both canonical cellular cAMP response elements (CREs) and the non-canonical viral CREs. CRTC1, specifically, is involved in CREB-mediated transcription of various neuronal immediate early genes (IEGs) as well as CREB-dependent hepatitis B virus (HBV) replication.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CRTC1
Applications Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 5F3.1
Formulation Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q6UUV9
Gene Symbols CRTC1; KIAA0616; MECT1; TORC1; WAMTP1
Host Species Mouse
Immunogen GST-tagged recombinant protein corresponding to human CRTC1/TORC-1 sequence within the N-terminal half..
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics and Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_001091952
Target Species Human, Mouse, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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