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MilliporeSigma™ Mouse anti-CST complex subunit CTC1, Clone: 8E5.2,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABE1015

Catalog No. MABE1015


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Description

Description

Specifically detects CST complex subunit CTC1 clone: 8E5.2 in Human samples, and it is validated for Western Blotting

CST complex subunit CTC1 (UniProt Q2NKJ3; also known as Conserved telomere maintenance component 1, HBV DNAPTP1-transactivated protein B) is encoded by the CTC1 (also known as C17orf68, CRMCC) gene (Gene ID 80169) in human. CTC1 is a subunit of the trimeric CST (CTC1, STN1, and TEN1) complex that binds ssDNA, promotes telomere DNA synthesis, and inhibits telomerase-mediated telomere elongation. CST directly interacts with and stimulates DNA polymerase α-primase (polα-primase) activity. CST also associates with and sequesters telomeric 3′ overhangs after their elongation by telomerase, thereby limiting further telomere extension by telomerase. Knockdown of either STN1 or CCT1 in human cancer cells and in mouse fibroblasts results in substantially elongated telomeric G-overhangs. Conditional deletion of CTC1 in mice leads to early entry into senescence and signs of telomeric replication defects, Human CTC1 gene mutations casue dyskeratosis congenita (DC) and related bone marrow failure syndromes, as well as the rare autosomal recessive neurological disorder Coats Plus, where patients develop cranial calcifications and cysts. Coats Plus and DC patients develop premature hair graying, anemia, and osteoporosis as a result of telomerase defects.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CST complex subunit CTC1
Monoclonal
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
CTC1; C17orf68; CRMCC
GST-tagged recombinant internal fragment from the C-terminal half of human CTC1.
100 μg
Epigenetics and Nuclear Function
NP_079375
Stable for one year at 2°C to 8°C from date of receipt.
IgG1 κ
Western Blot
8E5.2
Q2NKJ3
Mouse
Protein G Purified
RUO
Primary
Human
Purified
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