CST3, Mouse, Clone: Cyst13, Abnova™

Mouse monoclonal antibody raised against native CST3.

Supplier:  Abnova Corporation MAB0422

Catalog No. 89-107-943

Description

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeq

Specifications

• Antigen: CST3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: CST3
• Gene Symbols: CST3
• Immunogen: Native purified human CST3.
• Regulatory Status: RUO
• Gene ID (Entrez): 1471
• Content And Storage: Store at 4°C.
• Isotype: IgG1

• Applications: ELISA
• Clone: Cyst13
• Description: Mouse monoclonal antibody raised against native CST3.
• Formulation: In PBS, pH 7.4 (0.09% sodium azide)
• Gene Alias: ARMD11/MGC117328
• Host Species: Mouse
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid